Comparison of Mac‐2 binding protein glycosylation isomer (<scp>M2BPGi</scp>) with <scp>AST</scp> to platelet ratio index (<scp>APRI</scp>), fibrosis 4 Score (<scp>FIB</scp>‐4), and nonalcoholic fatty liver disease (<scp>NAFLD</scp>) fibrosis score (<scp>NFS</scp>) for <scp>NAFLD</scp> patients

نویسندگان

چکیده

The serum level of Mac-2 binding protein glycosylation isomer (M2BPGi) has been found to increase with the severity liver fibrosis in biopsy-proved nonalcoholic fatty disease (NAFLD). However, comparison M2BPGi noninvasive markers such as AST platelet ratio index (APRI), Fibrosis 4 Score (FIB-4), and NAFLD score (NFS) patients remains unclear. participants Tzu Chi cohort (TCNC) including health controls or were enrolled Taipei Hospital. was defined imaging without hepatitis B virus (HBV), C (HCV), drug, alcohol, other known causes chronic disease. A total 777 subjects included for final analysis. levels correlated APRI, FIB-4 score, NFS, respectively (P < .001). Of them, 376 (48.4%) 401 healthy controls. In group patients, significantly higher female than those male = .027 0.006, respectively). Categorized by age, elder age groups either .05). Compared controls, had BMI, waist circumference, metabolic components, .05), but no difference .685). According “intermediate- high-risk group” low-risk group. three biomarkers NFS. They population. Furthermore, different between score. determine risk fibrosis, also low “intermediate high risk” suggesting a surrogate marker assessing patients.

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ژورنال

عنوان ژورنال: Advances in Digestive Medicine

سال: 2022

ISSN: ['2351-9797', '2351-9800']

DOI: https://doi.org/10.1002/aid2.13315